Chem. Sci., 6. October 2017, Advance Article                                                     http://DOI: http://10.1039/C7SC03912C Steffan K. Kristensen, Espen Z. Eikeland, Esben Taarning, Anders T. Lindhardt  and  Troels Skrydstrup  A protocol for the Pd-catalysed cyanation of aryl bromides using near stoichiometric and gaseous hydrogen cyanide is reported for the first time. A two-chamber reactor was adopted for the safe liberation of ex situ.. read more →

Nat. Comm., 2017, 8, 489, doi:10.1038/s41467-017-00559-8 Mikkel T. Jensen, Magnus H. Rønne, Anne K. Ravn, René W. Juhl, Dennis U. Nielsen, Xin-Ming Hu, Steen U. Pedersen, Kim Daasbjerg, Troels Skrydstrup   Significant efforts have been devoted over the last few years to develop efficient molecular electrocatalysts for the electrochemical reduction of carbon dioxide to carbon.. read more →

ACS Catal., 2017, 7 (9), pp 6089–6093 http://DOI: 10.1021/acscatal.7b02179 Dorrit B. Nielsen, Benjamin A. Wahlqvist, Dennis U. Nielsen, Kim Daasbjerg and Troels Skrydstrup.     We report on an efficient Ir-catalyzed decarbonylation of glycerol, which could be coupled to an ensuing Pd-catalyzed alkoxycarbonylation of styrenes. The formation of hydrogen could be avoided by employing 1,4-benzoquinone.. read more →

Synlett M. Flinker, S. Lopez, D. U. Nielsen, K. Daasbjerg, F. Jensen og T. Skrydstrup http://DOI: 10.1055/s-0036-1590840   Three disilanes, (CH3)3SiSi(CH3)3, Cl(CH3)2SiSi(CH3)2Cl, and Cl2(CH3)SiSi(CH3)Cl2, all representing components of the Direct Process residue for the industrial synthesis of chloromethylsilanes, were evaluated for their abilities to reduce carbon dioxide to carbon monoxide upon treatment with fluoride salts… read more →

Angew. Chem. Int. Ed. 2017, 56, 6468. X.-M. Hu, M. H. Rønne, S. U. Pedersen, T. Skrydstrup and K. Daasbjerg http://DOI: 10.1002/anie.201701104           In a comparative study of the electrocatalytic CO2 reduction, cobalt meso-tetraphenylporphyrin (CoTPP) is used as a model molecular catalyst under both homogeneous and heterogeneous conditions. In the former.. read more →

Angew. Chem. Int. Ed. 2017, 56, 4549. T. L. Andersen, P. Nordeman, H. F. Christoffersen, H. Audrain, G. Antoni and Troels Skrydstrup http://DOI: 10.1002/anie.201700446         A mild and effective method is described for 11C-labeling of peptides selectively at the N-terminal nitrogen or at internal lysine positions. The presented method relies on the.. read more →

J. Org. Chem. 2017 H. Yin and T. Skrydstrup http://DOI: 10.1021/acs.joc.7b00942.     A simple method for accessing perfluoroalkyl-substituted enones is described applying a four-component palladium-catalyzed carbonylative coupling of aryl boronic acids together with terminal alkynes and perfluoroalkyl iodides in the presence of carbon monoxide. A wide range of highly functionalized enones can thus be.. read more →

J. Org. Chem. H. Yin and T. Skrydstrup http://DOI: 10.1021/acs.joc.7b00942.       A simple method for accessing perfluoroalkyl-substituted enones is described applying a four-component palladium-catalyzed carbonylative coupling of aryl boronic acids together with terminal alkynes and perfluoroalkyl iodides in the presence of carbon monoxide. A wide range of highly functionalized enones can thus be.. read more →

        Organometallics, Article ASAP http://DOI: 10.1021/acs.organomet.6b00893 Thomas L. Andersen, Søren Kramer, Jacob Overgaard, and Troels Skrydstrup Palladium(II) dialkyl complexes have previously been studied for their formation of alkanes through reductive elimination. More recently, these complexes, especially L2Pd(CH2TMS)2 derived from Pd(COD)(CH2TMS)2, have found general use as palladium(0) precursors for stoichiometric formation of oxidative.. read more →

ACS Catal., 2017, 7, 1392–1396
Martin Juhl, Simon L. R. Laursen, Yuxing Huang, Dennis U. Nielsen*, Kim Daasbjerg, and Troels Skrydstrup* read more →

Journal of Labelled Compounds and Radiopharmaceuticals http://DOI: 10.1002/jlcr.3470 Karoline T. Neumann, Anders T. Lindhardt*, Benny Bang-Andersen, Troels Skrydstrup* A new synthetic route to the Tau binder, THK-523, is disclosed herein, which can easily be adapted to 13C- and D-isotope labeling. The synthesis proceeds via two key reactions, namely, a Pd-catalyzed carbonylative Sonogashira coupling and a.. read more →