Angew. Chem. Int. Ed., 2017, 29. November

http://DOI: 10.1002/anie.201710089

Thomas L. Andersen, Aske S. Donslund, Karoline T. Neumann and Troels Skrydstrup

An efficient catalytic protocol for the three-component assembly of benzyl bromides, carbon monoxide and alkyl zinc reagents to benzyl alkyl ketones is described, representing the first Ni-catalyzed carbonylative coupling of two sp3-carbon fragments. The method, which relies on the application of NN2-type pincer ligand nickel complexes and a controlled release of CO gas from a solid precursor, works well with a range of benzylic bromides. Mechanistic studies suggest the intermediacy of carbon-centered radicals.