Anders T. Lindhardt, a* Roger Simonssen, b Rolf H. Taaning, a* Thomas M. Gøgsig, a Göran N. Nilsson, b Gunnar Stenhagen, b Charles S. Elmore, b and Troels Skrydstrup a*

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Julie L. H. Madsen,† Thomas L. Andersen,† Salvatore Santamaria,‡,§ Hideaki Nagase,‡,§ Jan J. Enghild,*,∥ and Troels Skrydstrup*, | J. Med. Chem. 2012, 55, 7900−7908 read more →

ACS Nano, 2012, 6, 6882 Nataliya Kalashnyk, Jakob T. Nielsen, Erik H. Nielsen, Troels Skrydstrup, Daniel E. Otzen, Erik Lægsgaard, Chen Wang, Flemming Besenbacher, Niels Chr. Nielsen, and Trolle R. Linderoth DOI: 10.1021/nn301708d ACS Nano, 2012, 6, 6882   Many severe diseases are associated with amyloid fibril deposits in the body caused by protein misfolding… read more →

J. Org. Chem., 2012, 77, 6155 http://DOI: 10.1021/jo3009337 Dennis U. Nielsen, Karoline Neumann, Rolf H. Taaning, Anders T. Lindhardt, Amalie Modvig, and Troels Skrydstrup A novel and general approach for 13C2– and 2H-labeled phenethylamine derivatives has been developed, based on a highly convergent single-step assembly of the carbon skeleton. The efficient incorporation of two carbon-13.. read more →

J. Org. Chem., 2012, 77, 5894 Geanna K. Min, Troels Skrydstrup DOI: 10.1021/jo300904z A highly regioselective Rh(I)-catalyzed hydrosilylation of enamides is presented. This mild protocol allows access to a wide variety of different arylsilanes with substitution at the β-position of the enamide and functionalization on the alkyl chain tethered to the silane. This protocol is extended.. read more →

J. Chem. Phys. 2012, 136, Article no. 204310 DOI:  J. L. Hansen, J. H. Nielsen, C. B. Madsen, A. T. Lindhardt, M. P. Johansson, T. Skrydstrup, L. B. Madsen and H. Stapelfeldt     We study how the combination of long and short laser pulses can be used to induce torsion in an.. read more →

J. Org. Chem., 2012, 77 (12),  5357 Mia N. Burhardt, Rolf Taaning, Niels Chr. Nielsen, and Troels Skrydstrup* DOI: 10.1021/jo300746x We have synthesized two isotopically labeled variants of the β-amyloid binding compound FSB possessing 13C-labels on the two terminal aryl carboxylic acid moieties. One of these was also fully deuterated on the olefinic spacers. The.. read more →

Org. Lett., 2012, 14, 2536 Thomas M. Gøgsig, Dennis U. Nielsen, Anders T. Lindhardt, and Troels Skrydstrup* DOI: 10.1021/ol300837d       The direct carbonylative palladium catalyzed synthesis of monoprotected 1,3-ketoaldehydes is reported starting from aryl iodides applying near stoichiometric amounts of carbon monoxide. Besides representing platforms for a variety of heterocyclic structures, these motives.. read more →

Org. Lett., 2012, 14, 2536 http://DOI:  10.1021/ol300837d T. M. Gøgsig, D. U. Nielsen, A. T. Lindhardt, T. Skrydstrup   A palladium catalyzed carbonylation of aryl iodides using near stoichiometric amounts of carbon monoxide enables the synthesis of monoprotected 1,3-ketoaldehydes. Besides representing platforms for a variety of heterocyclic structures, these motives serve as viable precursors for.. read more →

Angew. Chem. 2012, 51, 4681 Søren Kramer, Prof. Dr. Troels Skrydstrup DOI:10.1002/anie.201200307   Furans of gold: The first example of a gold-catalyzed intermolecular addition of carbon ylides to terminal alkynes is reported (see scheme; DCE=dichloroethane, Tf=trifluoromethanesulfonyl). Subsequent intramolecular trapping of the generated gold carbene completes a formal [3+2] cycloaddition, which represents a novel synthesis of.. read more →

Amelia‐Elena Rotaru ,Wei Jiang, Kai Finster, Troels Skrydstrup, Rikke Louise Meyer DOI: 10.1002/bit.24500 Bioeng., 2012, 109, 1889 The use of microorganisms as support for reduction of dissolved Pd(II) to immobilized Pd(0) nanoparticles is an environmentally friendly approach for Pd recovery from waste. To better understand and engineer Pd(0) nanoparticle synthesis, one has to consider the mechanisms.. read more →

J. Org. Chem., 2012, 77, 3793 Klaus Bjerglund, Anders T. Lindhardt, and Troels Skrydstrup DOI: 10.1021/jo3000767 The palladium-catalyzed carbonylation of urea derivatives with aryl iodides and bromides afforded N-benzoyl ureas (20 examples) in yields attaining quantitative via the application of near-stoichiometric amounts of carbon monoxide generated from the decarbonylation of the CO precursor, 9-methylfluorene-9-carbonyl chloride… read more →

Encyclopedia of Radicals in Chemistry, Biology and Materials, 2012 Susannah C. Coote, Robert A. Flowers II, Troels Skrydstrup, David J. Procter DOI: 10.1002/9781119953678.rad025 Samarium diiodide (SmI2) is a one-electron reducing agent that is employed extensively in organic synthesis to bring about a wide variety of transformations. Its ability to mediate both radical and anionic processes.. read more →

Biochim. Biophys. Acta 2012, 1824, 274-285. doi:10.1016/j.bbapap.2011.10.014 Maria Andreasen, Søren B. Nielsen, Tina Mittag, Morten Bjerring, Jakob T. Nielsen, Shuai Zhang, Erik H. Nielsen, Martin Jeppesen, Gunna Christiansen, Flemming Besenbacher, Mingdong Dong, Niels Chr. Nielsen, Troels Skrydstrup, Daniel E. Otzen   The well-ordered cross β-strand structure found in amyloid aggregates is stabilized by many different.. read more →

Org. Lett., 2012, 14 , 284 Zhuo Xin, Thomas M. Gøgsig, Anders T. Lindhardt, and Troels Skrydstrup* DOI: 10.1021/ol203057w The palladium-catalyzed alkoxycarbonylation of aryl bromides is described for the efficient preparation of tertiary esters. The protocol proved compatible with a wide variety of functionalized (hetero)aromatic bromides, as well as several different sterically hindered tertiary alcohols,.. read more →

Angew. Chem., 2012, 51, 798 Thomas M. Gøgsig, Dr. Rolf H. Taaning, Dr. Anders T. Lindhardt, Prof. Dr. Troels Skrydstrup DOI: 10.1002/anie.201107494 With a hint of CO: The first Pd-catalyzed carbonylative α-arylations of simple ketones with carbon monoxide is presented for the direct synthesis of 1,3-diketones (see scheme). The method uses only stoichiometric amounts of.. read more →

J. Am. Chem. Soc., 2012, 134, 443 Thomas M. Gøgsig, Jonatan Kleimark, Sten O. Nilsson Lill, Signe Korsager, Anders T. Lindhardt, Per-Ola Norrby, and Troels Skrydstrup DOI: 10.1021/ja2084509   A new efficient protocol for the nickel-catalyzed Heck reaction of aryl triflates with vinyl ethers is presented. Mild reaction conditions that equal those of the corresponding.. read more →

Biotechnol. Bioeng. 2012 109, 45 Hosseinkhani B, Søbjerg LS, Rotaru AE, Emtiazi G, Skrydstrup T, Meyer RL. DOI: 10.1002/bit.23293     Bimetallic nanoparticles are considered the next generation of nanocatalysts with increased stability and catalytic activity. Bio-supported synthesis of monometallic nanoparticles has been proposed as an environmentally friendly alternative to the conventional chemical and physical.. read more →

J. Phys. Chem. 2012, 116, 7652 http://DOI: 10.1021/jp2098679 Claudia U. Hjørringgaard, Brian S. Vad, Vladimir V. Matchkov, Søren B. Nielsen, Thomas Vosegaard, Niels Chr. Nielsen, Daniel E. Otzen, and Troels Skrydstrup   Bacterial resistance to classical antibiotics is a serious medical problem, which continues to grow. Small antimicrobial peptides represent a potential solution and are.. read more →