Biochim. Biophys. Acta 2015, 1854, 1890. H. F. Christoffersen, M. Andreasen, S. Zhang, E. H. Nielsen, G. Christiansen, M. D. Dong, T. Skrydstrup and D. E. Otzen DOI: 10.1016/j.bbapap.2015.08.005. Applying fibril-forming peptides in nanomaterial design is still challenged by the difficulties in understanding and controlling how fibrils form. The present work investigates the influence of.. read more →

J. Am. Chem. Soc., 2015, 137,14043 I. S. Makarov, T. Kuwahara, X. Jusseau, I. Ryu, A. T. Lindhardt and T. Skrydstrup       DOI: http://10.1021/jacs.5b09342 The first Pd-catalyzed carbonylative couplings of aryl and vinyl halides with vinylogous enolates are reported generating products derived from C–C bond formation exclusively at the γ-position. Good results were.. read more →

Transition Metal Catalyzed Carbonylative Synthesis of Heterocycles Volume 42 of the series Topics in Heterocyclic Chemistry pp 89-99 http://10.1007/7081_2015_160   Dennis U. Nielsen, Zhong Lian, Anders T. Lindhardt, Troels Skrydstrup   In this chapter, representative examples from the literature are illustrated for the construction of heterocycles from palladium-catalyzed carbonylation reactions of aryl halides. Remarkably, the catalytic systems are highly efficient in.. read more →

Angew. Chem. Int. Ed. 2015, 54, 6862. Z. Xin, C. Lescot, S. D. Friis, K. Daasbjerg and T. Skrydstrup DOI: 10.1002/anie.201500233 The first organocatalyzed trapping of CO2 through CC and CO bond formation is reported. Alkynyl indoles together with catalytic amounts of an organic base and five equivalents of CO2 resulted in the formation new.. read more →

Org. Lett., 2015, 17, 2094 K. T. Neumann, A. T. Lindhardt. B. B. Andersen and T. Skrydstrup DOI: 10.1021/acs.orglett.5b00642   A sequential one-pot procedure for the synthesis of either 2-(hetero)aryl or 2-styryl benzoxazoles is reported, starting from aryl and vinyl bromides, respectively, involving an initial aminocarbonylation with 2-aminophenols as nucleophiles followed by an acid mediated.. read more →

Langmuir, 2015, 31,  4443 K. Torbensen, M. Kongsfelt, K. Shimizu, E. B. Pedersen, T. Skrydstrup, S. U. Pedersen and K. Daasbjerg DOI: 10.1021/la504500m   A simple, direct, and versatile scanning electrochemical microscopy (SECM) approach for local carboxylation of multilayered graphene on nickel is demonstrated, in which carbon dioxide serves as the carboxylation agent under reductive.. read more →

Chem. Commun., 2015,51, 7831 Zhong Lian, Hongfei Yin, Stig D. Friis and Troels Skrydstrup DOI: http://10.1039/C5CC02085A   The first transition-metal catalysed carbonylation with a phosphorus nucleophile is presented. This transformation provides efficient and mild access to aroylphosphonates under mild conditions, thus ensuring a broad substrate scope. The utility of aroylphosphonates as useful reagents, capable of.. read more →

Biochim. Biophys. Acta 2015, 1854, 882. H. F. Christoffersen, S. K. Hansen, B. S. Vad, E. H. Nielsen, J. T. Nielsen, T. Vosegaard, T. Skrydstrup and D. E. Otzen DOI: http://10.1016/j.bbapap.2015.03.003 The medium-length fungal peptaibol SPF-5506-A(4) has been shown to inhibit formation of the Aβ peptide involved in Alzheimer”s disease. As Aβ is a cleavage-product.. read more →

Org. Lett., 2015, ASAP
Hongfei Yin, Angelina M. de Almeida, Mauro V. de Almeida, Anders T. Lindhardt*, and Troels Skrydstrup*
dx.doi.org/10.1021/acs.orglett.5b00221

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J. Am. Chem. Soc., 2015, 137, 1548–1555
Thomas L. Andersen, Stig D. Friis, Helene Audrain, Patrik Nordeman, Gunnar Antoni and Troels Skrydstrup dx.doi.org/ 10.1021/ja511441u

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Chem. Commun., 2015, in press
Lian, Zhong; Friis, Stig D.; Skrydstrup, Troels doi:10.1039/C5CC00123D

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J. Org. Chem., 2015, 80, 1920-1928
Angelina M. de Almeida, Thomas L. Andersen, Anders T. Lindhardt, Mauro V. de Almeida and Troels Skrydstrup dx.doi.org/10.1021/jo5025464

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Chem. Commun., 2015,51, 3600 Z. Lian, S. D. Friis and T. Skrydstrup DOI: http://10.1039/C5CC00123D A simple and mild Pd-catalysed carbonylative α-arylation of nitromethane has been realised providing access to α-nitro aryl ketones from an array of aryl and heteroaryl iodides. The methodology requires only a mild base and uses the convenient solid CO releasing molecule, COgen.. read more →

Chem. Commun., 2015,51, 3600-3603 http://DOI:  10.1039/C5CC00123D Zhong Lian, Stig D. Friis and Troels Skrydstrup*         A simple and mild Pd-catalysed carbonylative α-arylation of nitromethane has been realised providing access to α-nitro aryl ketones from an array of aryl and heteroaryl iodides. The methodology requires only a mild base and uses the convenient solid CO.. read more →

Chem. Commun., 2015, 51, 1870-1873
Lian, Zhong; Friis, Stig D.; Skrydstrup, Troels
DOI: 10.1039/C4CC09303H

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Chem. Commun., 2015, 51, 1870 Zhong Lian, Stig D. Friis and Troels Skrydstrup DOI: 10.1039/C4CC09303H The carbonylative coupling of aryl and heteroaryl bromides with polyfluoroarenes via palladium-catalyzed C–H activation is presented. This transformation proceeds efficiently at moderate reaction temperatures and does not require strong base or reactive intermediates. A near stoichiometric amount of CO is sufficient.. read more →